Check out Diana's list later tonight when she posts it.
Harry Potter Series by J.K. Rowlings -- It will take a long time for any series to even come close to matching this one.
The Amazing Adventures of Kavalier & Clay by Michael Chabon (2000) -- I'm not sure the Great American Novel really exist, but this book is one of the closest things to it I've ever read.
A Heartbreaking Work of Staggering Genius by Dave Eggers (2000) -- This book isn't Eggers' greatest, but I appreciate it for the movement that followed; I'm not sure McSweeney's would have exploded w/o it.
Chronicles by Bob Dylan (2004) -- Every once and awhile a memoir will come out that seems at times more like reading history than about someone's life; that's what this book is. Dylan remains reserved about his life as he always is, but does give true insight into the village life, and the folk movement.
Consider the Lobster by David Foster Wallace (2005) -- Wallace invented the creative non-fiction...read this awesome collection of essays if you want to know why.
Jarhead by Anthony Swofford (2005) -- Best war book I've read over the past 10 years.
Walt Disney: The Triumph of the American Imagination by Neal Gabler (2006) -- Living in Anaheim, I'm always a sucker to hear any Disney history; this bio on Walt is the best out there.
Dwelling Places: A Novel by Vinita Hampton Wright (2006) --When it comes to well written Christian fiction, Wright is the best there is (actually she's about the only one there is); she rights about themes many Christians just pretend don't exist (like depression)
Velvet Elvis by Rob Bell (2006) -- I've heard people say The Case for Christ is a modern version of Mere Christianity; I can see that...except for the fact that the book is lousy. Bell's book makes a better case for comparison.
The Hunger Games by Suzanne Collins (2008) -- This is the best series I've read sense Harry Potter ended.